Lamotrigine after corpus callosotomy

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Lamotrigine after corpus callosotomy

Corpus callosotomy (CC) has been employed in the management of intractable epilepsy since 1940’ and should be considered for patients with generalized falling seizures with physical injury, recurrent life-threatening generalized convulsive status epilepticus or atypical absence status’. CC is especially useful in improving seizure control in patients with tonic and atonic seizures3 and those wi...

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Reinventing the corpus callosotomy.

Surgical section of the corpus callosum is an old operation. It was first performed to treat epilepsy more than 75 years ago. Early procedures often consisted of a “total commissurotomy,” performed through a right frontoparietal craniotomy, with division of the entire corpus callosum, the ipsilateral fornix, the anterior commissure, and even the massa intermedia of the thalamus. Subsequently, s...

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Long-term follow-up of seizure outcomes after corpus callosotomy

PURPOSE Corpus callosotomy can be an effective surgical treatment for medically intractable generalized seizures, particularly for drop attacks. We studied long-term seizure outcomes after callosotomy, mainly focusing on drop attacks as the seizure type. METHODS This study reviews 78 patients who underwent callosotomy and were followed up for more than 3 years after surgery. Seizure outcome o...

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Quantitative analysis of cortical pyramidal neurons after corpus callosotomy.

This study quantitatively explored the dendritic/spine extent of supragranular pyramidal neurons across several cortical areas in two adult male subjects who had undergone a callosotomy several decades before death. In all cortical areas, there were numerous atypical, supragranular pyramidal neurons with elongated "tap root" basilar dendrites. These atypical cells could be associated with an un...

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Corpus callosotomy in refractory idiopathic generalized epilepsy

RATIONALE A small percentage of patients with idiopathic generalized epilepsy (IGE) do not respond to medical therapy. Generalized tonic-clonic (GTC) seizures are especially debilitating and can be associated with severe injuries. The benefit, safety and effect of corpus callosotomy (CC) in patients with IGE have not been studied. METHODS We reviewed patients with presumed IGE who underwent C...

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ژورنال

عنوان ژورنال: Seizure

سال: 1997

ISSN: 1059-1311

DOI: 10.1016/s1059-1311(97)80027-1